It's best to pull a cantankerous weed early.

Even if it takes a lot of muscle, clear the bed fully before you sow the crops.  It becomes impossible to pull once the vegetables start to grow.  And every time you reach in to harvest a yellow squash, there is that weed, strong and deep and intractable and leaching the nutrients from your precious plantings' soil.

Besides, the best bugs are always hiding in the roots.